Macmillan Cancer Support is planning to cut 150 jobs after a review of its services.
The charity, which employs more than 2,000 people, has estimated these redundancies will save about £7m a year.
The charity said it would cut the roles because it had felt “the impact of a difficult financial environment”, citing rising inflation.
A Macmillan spokesperson said: “It is getting harder to raise money, and inflation means it costs more to do the same as we did a few years ago.
“We are tackling these challenges by transforming, so we can have more impact for people with cancer, but without relying on raising more money to be able to do that.
“This has meant taking the difficult decision to reduce the size of the organisation and sadly means we must make some valued colleagues redundant.
“We are taking these difficult decisions, and building a new strategy, to ensure Macmillan is in the best possible position to provide the vital support people living with cancer need now and long into the future.”
The charity’s spokesperson told Third Sector the impact of cuts would be felt across various teams throughout the organisation.
They said the timescale for redundancies was “ongoing” and had “various different end points”, with a consultation with affected staff already underway.
Macmillan’s most recent accounts show that in 2022 its income fell by £3.6m on the previous year to £227.1m, while expenditure rose to £251.7m.
This was part of a strategy to spend down its cash reserves “to have the biggest impact for people living with cancer at a time when need is particularly great”, the charity said at the time.